Research Articles
Unlocking Metabolic Health: A Comprehensive Guide to Multi-Omics Biomarker Discovery for Research and Drug Development
This article provides a comprehensive roadmap for researchers, scientists, and drug development professionals engaged in multi-omics biomarker discovery for metabolic disorders.
Decoding Diabetes Pathogenesis: A Comprehensive Guide to Beta Cell Deficiency vs. Insulin Resistance Biomarkers for Precision Therapeutics
This article provides a detailed, research-oriented analysis of biomarkers distinguishing beta cell dysfunction from insulin resistance—the two core pathological pillars of diabetes mellitus.
Lipid Biomarkers at the Crossroads: Unraveling Their Dual Role in Cancer Risk and Diabetes Pathogenesis
This comprehensive review synthesizes current research on lipid metabolism biomarkers as critical nexus points linking cancer risk and diabetes.
Decoding the Powerhouse: Novel Mitochondrial Dysfunction Biomarkers in Metabolic Syndrome Pathogenesis and Therapeutics
This article provides a comprehensive analysis for researchers, scientists, and drug development professionals on the evolving role of mitochondrial dysfunction biomarkers in metabolic syndrome (MetS).
GDF-15 in Metabolic Disease: From Stress Response Hormone to Therapeutic Target for Diabetes and Obesity
This article provides a comprehensive analysis of Growth Differentiation Factor 15 (GDF-15) as a critical mediator in metabolic homeostasis, with a focus on its therapeutic potential for diabetes and obesity.
Leptin and Adiponectin in Metabolic Syndrome: Molecular Mechanisms, Therapeutic Targets, and Clinical Implications
This comprehensive review synthesizes the latest research on the pivotal roles of the adipokines leptin and adiponectin in the pathogenesis of metabolic syndrome (MetS).
Biomarkers in MAFLD: From Pathogenesis Discovery to Clinical Trial Endpoints
This review provides a comprehensive analysis of the current and emerging biomarker landscape for metabolic dysfunction-associated fatty liver disease (MAFLD).
GSDMD Pyroptosis as a Key Driver: Linking Inflammatory Biomarkers to Insulin Resistance Mechanisms
This review synthesizes current research on the molecular interplay between inflammatory biomarkers, insulin resistance (IR), and the executioner protein Gasdermin D (GSDMD)-mediated pyroptosis.
Epigenetic Clocks and Clinical Frontiers: DNA Methylation Biomarkers for Type 2 Diabetes Prediction, Progression, and Personalized Therapy
This comprehensive review examines the rapidly evolving field of DNA methylation biomarkers for Type 2 Diabetes (T2D).
Metabolite-Metabolite Interaction Networks: From Construction to Application in Biomedical Research and Drug Discovery
This article provides a comprehensive overview of metabolite-metabolite interaction network analysis, a pivotal approach in systems biology for understanding complex metabolic processes.