Research Articles
Decoding Disease Through Metabolic Networks: From Systems Biology to Clinical Applications
This article provides a comprehensive overview of how metabolic networks are reconstructed, analyzed, and applied to understand complex human diseases.
Emerging Biomarkers for Metabolic Syndrome and Type 2 Diabetes: From Pathophysiology to Precision Medicine
This comprehensive review synthesizes the latest advancements in biomarker science for Metabolic Syndrome (MetS) and Type 2 Diabetes Mellitus (T2DM), targeting researchers and drug development professionals.
Basal Metabolic Rate (BMR): Physiological Determinants, Clinical Significance, and Applications in Biomedical Research
This article provides a comprehensive analysis of Basal Metabolic Rate (BMR) for researchers, scientists, and drug development professionals.
Metabolite Set Enrichment Analysis (MSEA): A Comprehensive Guide for Pathway Discovery in Biomedical Research
This article provides a comprehensive guide to Metabolite Set Enrichment Analysis (MSEA), a powerful bioinformatic method for interpreting metabolomic data by identifying biologically meaningful patterns in metabolic pathways.
Healthy Core Metabolism: Defining the Physiological Basis for Preventive Health and Drug Development
This article synthesizes the concept of a 'Healthy Core Metabolism' (HCM) as a stable, optimal physiological state crucial for long-term health and disease prevention.
Exploratory Metabolomics of Metabolic Syndrome: Unveiling Biomarkers for Pathophysiology, Diagnosis, and Therapeutic Development
Metabolic syndrome (MetS), a cluster of conditions increasing the risk of cardiovascular disease and type 2 diabetes, presents a significant global health challenge.
Untargeted Metabolomics: A Comprehensive Guide to Global Metabolic Profiling in Disease Research and Drug Discovery
Untargeted metabolomics provides an unbiased, comprehensive analysis of the complete set of small-molecule metabolites in a biological system, offering a direct snapshot of biochemical activity and physiological status.
Volatile Metabolite Analysis by GC-MS: From Fundamentals to Advanced Applications in Biomedical Research
This article provides a comprehensive guide to Gas Chromatography-Mass Spectrometry (GC-MS) for analyzing volatile metabolites, tailored for researchers and drug development professionals. It covers foundational principles, exploring why GC-MS is considered a 'gold standard' in metabolomics for its superior reproducibility and rich spectral libraries. The scope extends to detailed methodological workflows, including sample preparation, derivatization, and advanced data integration with machine learning. The article also delivers practical troubleshooting and optimization strategies to enhance sensitivity and resolution, and concludes with rigorous method validation protocols and comparative analyses with other techniques like LC-MS, providing a complete resource for implementing robust GC-MS assays in biomedical and clinical research.
The Iron Paradox: How a Tiny Atom Shapes Your Health and Fights Disease
Explore the fascinating world of iron metabolism - from absorption and regulation to groundbreaking discoveries in cancer research and disease treatment.
Seeing the Unseeable: A New Window into Our Metabolic Engine
Scientists are now watching the human kidney process fuel in real-time using deuterium metabolic imaging, revealing secrets that could transform our fight against diabetes and kidney disease.